Drug interactions
ciprofloxacin + clozapine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ clozapine levels → seizures/QT/AE risk.
Mechanism of action
CYP1A2 inhibition.
Clinical management
Avoid or reduce dose with level/AE monitoring.
Drug reference
References
Frequently asked questions
Can I take ciprofloxacin with clozapine?
The interaction is rated: Major. ↑ clozapine levels → seizures/QT/AE risk.
How serious is the interaction between ciprofloxacin and clozapine?
The interaction is rated: Major. Evidence level: High.
How is the interaction between ciprofloxacin and clozapine managed?
Avoid or reduce dose with level/AE monitoring.
Why do ciprofloxacin and clozapine interact?
CYP1A2 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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