Drug interactions
Ciprofloxacin + Diazepam
Severity: Minor
Ciprofloxacin and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin may modestly reduce diazepam clearance, raising its levels and prolonging sedation. Quinolones can also cause CNS stimulation, and both effects are generally small.
What this interaction means in plain words
Ciprofloxacin and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Diazepam belongs to Musculoskeletal.
Why it happens
Ciprofloxacin may weakly inhibit hepatic metabolism of diazepam, reducing its clearance.
What to do
Be aware of possible increased sedation, particularly in elderly patients or with repeated diazepam dosing, and reduce the dose if drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Diazepam?
MediHelp rates the interaction as minor. Ciprofloxacin and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin may modestly reduce diazepam clearance, raising its levels and prolonging sedation. Quinolones can also cause CNS stimulation, and both effects are generally small.
How serious is the interaction between Ciprofloxacin and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of possible increased sedation, particularly in elderly patients or with repeated diazepam dosing, and reduce the dose if drowsiness occurs.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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