Drug interactions
Ciprofloxacin + Didanosine
Severity: Moderate
Ciprofloxacin and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chewable or buffered didanosine formulations contain aluminum and magnesium that bind ciprofloxacin and lower its absorption. This may cause treatment failure of the antibiotic.
What this interaction means in plain words
Ciprofloxacin and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Didanosine belongs to Anti Virals.
Why it happens
Chelation of ciprofloxacin by the polyvalent cations in buffered didanosine formulations.
What to do
Give oral ciprofloxacin at least 2 hours before or 6 hours after buffered didanosine. Enteric-coated didanosine does not contain these buffers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Ciprofloxacin with Didanosine?
MediHelp rates the interaction as moderate. Ciprofloxacin and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chewable or buffered didanosine formulations contain aluminum and magnesium that bind ciprofloxacin and lower its absorption. This may cause treatment failure of the antibiotic.
How serious is the interaction between Ciprofloxacin and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral ciprofloxacin at least 2 hours before or 6 hours after buffered didanosine. Enteric-coated didanosine does not contain these buffers.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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