Drug interactions
Ciprofloxacin + Erlotinib
Severity: Moderate
Ciprofloxacin and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin can increase erlotinib exposure, which may worsen rash, diarrhea and other dose-related adverse effects. The effect is mainly relevant during longer courses of ciprofloxacin.
What this interaction means in plain words
Ciprofloxacin and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Erlotinib belongs to Oncology.
Why it happens
Ciprofloxacin inhibits CYP1A2 and CYP3A4 pathways contributing to erlotinib metabolism, reducing its clearance.
What to do
Monitor for erlotinib toxicity such as severe diarrhea and rash during co-therapy. Reduce the erlotinib dose in steps if severe reactions occur, or use another antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Ciprofloxacin with Erlotinib?
MediHelp rates the interaction as moderate. Ciprofloxacin and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin can increase erlotinib exposure, which may worsen rash, diarrhea and other dose-related adverse effects. The effect is mainly relevant during longer courses of ciprofloxacin.
How serious is the interaction between Ciprofloxacin and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity such as severe diarrhea and rash during co-therapy. Reduce the erlotinib dose in steps if severe reactions occur, or use another antibiotic.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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