Drug interactions
Ciprofloxacin + Etrasimod
Severity: Moderate
Ciprofloxacin and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can slow heart rate and AV conduction at initiation, and ciprofloxacin can prolong the QT interval. Together the bradycardia and QT prolongation could increase torsades risk, especially in patients with cardiac disease.
What this interaction means in plain words
Ciprofloxacin and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive effects: S1P receptor modulation slows heart rate while fluoroquinolone hERG blockade prolongs repolarization.
What to do
Obtain an ECG before starting etrasimod and monitor heart rate and rhythm in patients on ciprofloxacin. Consider cardiology input if baseline QT prolongation is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Ciprofloxacin with Etrasimod?
MediHelp rates the interaction as moderate. Ciprofloxacin and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can slow heart rate and AV conduction at initiation, and ciprofloxacin can prolong the QT interval. Together the bradycardia and QT prolongation could increase torsades risk, especially in patients with cardiac disease.
How serious is the interaction between Ciprofloxacin and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting etrasimod and monitor heart rate and rhythm in patients on ciprofloxacin. Consider cardiology input if baseline QT prolongation is present.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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