Drug interactions
Ciprofloxacin + Fludrocortisone
Severity: Moderate
Ciprofloxacin and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones carry a risk of tendinopathy and tendon rupture, and concurrent corticosteroid exposure raises that risk further. Fludrocortisone has mainly mineralocorticoid activity, but it still has some glucocorticoid effect, so the risk is plausible although less well documented. Older patients and those with renal impairment or transplants are most susceptible.
What this interaction means in plain words
Ciprofloxacin and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Fludrocortisone belongs to Endocrine.
Why it happens
Additive tendon toxicity from fluoroquinolone-induced collagen and tenocyte damage combined with corticosteroid effects on connective tissue.
What to do
Consider a non-fluoroquinolone antibiotic where possible, especially in elderly patients. If the combination is used, tell the patient to stop ciprofloxacin and seek review at the first sign of tendon pain or swelling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Ciprofloxacin with Fludrocortisone?
MediHelp rates the interaction as moderate. Ciprofloxacin and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones carry a risk of tendinopathy and tendon rupture, and concurrent corticosteroid exposure raises that risk further. Fludrocortisone has mainly mineralocorticoid activity, but it still has some glucocorticoid effect, so the risk is plausible although less well documented. Older patients and those with renal impairment or transplants are most susceptible.
How serious is the interaction between Ciprofloxacin and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-fluoroquinolone antibiotic where possible, especially in elderly patients. If the combination is used, tell the patient to stop ciprofloxacin and seek review at the first sign of tendon pain or swelling.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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