Drug interactions
Ciprofloxacin + Glipizide-metformin
Severity: Moderate
Ciprofloxacin and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as ciprofloxacin can cause both hypoglycemia and hyperglycemia, particularly in patients taking sulfonylureas. Severe and occasionally prolonged hypoglycemia has been reported, with older and renally impaired patients at greatest risk.
What this interaction means in plain words
Ciprofloxacin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Glipizide-metformin belongs to Endocrine.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release and may modestly raise sulfonylurea exposure, causing dysglycemia.
What to do
Monitor blood glucose closely during and shortly after the antibiotic course and teach the patient to recognise hypoglycemia. Reduce the glipizide dose or choose a non-quinolone antibiotic if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Glipizide-metformin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as ciprofloxacin can cause both hypoglycemia and hyperglycemia, particularly in patients taking sulfonylureas. Severe and occasionally prolonged hypoglycemia has been reported, with older and renally impaired patients at greatest risk.
How serious is the interaction between Ciprofloxacin and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and shortly after the antibiotic course and teach the patient to recognise hypoglycemia. Reduce the glipizide dose or choose a non-quinolone antibiotic if glucose becomes unstable.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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