Drug interactions
Ciprofloxacin + Glyburide-metformin
Severity: Moderate
Ciprofloxacin and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as ciprofloxacin can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs. Severe hypoglycemia has been reported, especially with sulfonylureas like glyburide and in older or renally impaired patients.
What this interaction means in plain words
Ciprofloxacin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Glyburide-metformin belongs to Endocrine.
Why it happens
Fluoroquinolones affect pancreatic beta-cell insulin release, adding to sulfonylurea action; ciprofloxacin may also inhibit CYP2C9.
What to do
Monitor blood glucose closely during and after the antibiotic course and counsel patients on hypoglycemia symptoms. Consider another antibiotic class if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Glyburide-metformin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as ciprofloxacin can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs. Severe hypoglycemia has been reported, especially with sulfonylureas like glyburide and in older or renally impaired patients.
How serious is the interaction between Ciprofloxacin and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after the antibiotic course and counsel patients on hypoglycemia symptoms. Consider another antibiotic class if glucose becomes unstable.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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