Drug interactions
Ciprofloxacin + Ibrutinib
Severity: Moderate
Ciprofloxacin and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is a moderate CYP3A4 inhibitor and may raise ibrutinib exposure. Higher ibrutinib levels increase the risk of bleeding, arrhythmia and other adverse effects.
What this interaction means in plain words
Ciprofloxacin and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Ibrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ibrutinib by ciprofloxacin.
What to do
Reduce the ibrutinib dose as advised for moderate CYP3A4 inhibitors in the labeling. Monitor for bleeding, atrial fibrillation and cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ciprofloxacin with Ibrutinib?
MediHelp rates the interaction as moderate. Ciprofloxacin and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin is a moderate CYP3A4 inhibitor and may raise ibrutinib exposure. Higher ibrutinib levels increase the risk of bleeding, arrhythmia and other adverse effects.
How serious is the interaction between Ciprofloxacin and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ibrutinib dose as advised for moderate CYP3A4 inhibitors in the labeling. Monitor for bleeding, atrial fibrillation and cytopenias.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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