Drug interactions
Ciprofloxacin + Ifosfamide
Severity: Minor
Ciprofloxacin and Ifosfamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a prodrug activated by CYP3A4 and CYP2B6, and CYP3A4 inhibition can shift it toward neurotoxic and nephrotoxic metabolites while reducing activation. Ciprofloxacin is only a weak CYP3A4 inhibitor, so any effect is probably small. Neutropenic patients on ifosfamide may nevertheless receive ciprofloxacin, so the combination does occur.
What this interaction means in plain words
Ciprofloxacin and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Ifosfamide belongs to Oncology.
Why it happens
Ciprofloxacin is a weak CYP3A4 inhibitor and could slightly alter the metabolic activation of ifosfamide.
What to do
No dose change is usually needed. Monitor for neurotoxicity and treatment response as part of routine ifosfamide care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Ifosfamide?
MediHelp rates the interaction as minor. Ciprofloxacin and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ifosfamide is a prodrug activated by CYP3A4 and CYP2B6, and CYP3A4 inhibition can shift it toward neurotoxic and nephrotoxic metabolites while reducing activation. Ciprofloxacin is only a weak CYP3A4 inhibitor, so any effect is probably small. Neutropenic patients on ifosfamide may nevertheless receive ciprofloxacin, so the combination does occur.
How serious is the interaction between Ciprofloxacin and Ifosfamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for neurotoxicity and treatment response as part of routine ifosfamide care.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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