Drug interactions
Ciprofloxacin + Istradefylline
Severity: Minor
Ciprofloxacin and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits P-glycoprotein and can raise exposure to P-gp substrates. Ciprofloxacin is only a weak P-gp substrate, so a clinically important rise is unlikely.
What this interaction means in plain words
Ciprofloxacin and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Istradefylline belongs to Central Nervous System.
Why it happens
P-glycoprotein inhibition by istradefylline that may modestly increase ciprofloxacin absorption.
What to do
No dose change is generally required. Watch for increased ciprofloxacin adverse effects such as nausea or CNS symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Ciprofloxacin with Istradefylline?
MediHelp rates the interaction as minor. Ciprofloxacin and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses inhibits P-glycoprotein and can raise exposure to P-gp substrates. Ciprofloxacin is only a weak P-gp substrate, so a clinically important rise is unlikely.
How serious is the interaction between Ciprofloxacin and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Watch for increased ciprofloxacin adverse effects such as nausea or CNS symptoms.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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