Drug interactions
Ciprofloxacin + Meclofenamic acid
Severity: Moderate
Ciprofloxacin and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may raise the risk of CNS stimulation and seizures. Patients with epilepsy, renal impairment or higher fluoroquinolone exposure are most vulnerable. Reports are mostly isolated.
What this interaction means in plain words
Ciprofloxacin and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive lowering of seizure threshold, with fluoroquinolone GABA-A antagonism possibly potentiated by NSAIDs.
What to do
Avoid in patients with seizure disorders or other CNS risk factors. Otherwise monitor for CNS excitation and consider another analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Meclofenamic acid?
MediHelp rates the interaction as moderate. Ciprofloxacin and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may raise the risk of CNS stimulation and seizures. Patients with epilepsy, renal impairment or higher fluoroquinolone exposure are most vulnerable. Reports are mostly isolated.
How serious is the interaction between Ciprofloxacin and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure disorders or other CNS risk factors. Otherwise monitor for CNS excitation and consider another analgesic.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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