Drug interactions
Ciprofloxacin + Meloxicam
Severity: Moderate
Ciprofloxacin and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the central nervous system stimulation and seizure risk of fluoroquinolones. The risk is low but is higher in patients with epilepsy, CNS disorders or renal impairment.
What this interaction means in plain words
Ciprofloxacin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Meloxicam belongs to Musculoskeletal.
Why it happens
Fluoroquinolone GABA-A antagonism may be potentiated by NSAIDs, lowering seizure threshold; the exact mechanism is not fully established.
What to do
Avoid the combination in patients with seizure history or other predisposing factors. Otherwise use lowest effective doses and counsel patients to report CNS symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Meloxicam?
MediHelp rates the interaction as moderate. Ciprofloxacin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the central nervous system stimulation and seizure risk of fluoroquinolones. The risk is low but is higher in patients with epilepsy, CNS disorders or renal impairment.
How serious is the interaction between Ciprofloxacin and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure history or other predisposing factors. Otherwise use lowest effective doses and counsel patients to report CNS symptoms.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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