Drug interactions
Ciprofloxacin + Propranolol
Severity: Minor
Ciprofloxacin and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin may modestly increase propranolol exposure, since propranolol is partly cleared via CYP1A2 which ciprofloxacin inhibits. This could cause more bradycardia or hypotension in some patients.
What this interaction means in plain words
Ciprofloxacin and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Propranolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP1A2-mediated propranolol side-chain oxidation by ciprofloxacin.
What to do
Monitor heart rate and blood pressure when ciprofloxacin is started or stopped; reduce the propranolol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Ciprofloxacin with Propranolol?
MediHelp rates the interaction as minor. Ciprofloxacin and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ciprofloxacin may modestly increase propranolol exposure, since propranolol is partly cleared via CYP1A2 which ciprofloxacin inhibits. This could cause more bradycardia or hypotension in some patients.
How serious is the interaction between Ciprofloxacin and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when ciprofloxacin is started or stopped; reduce the propranolol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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