Drug interactions
Ciprofloxacin + Rasagiline
Severity: Moderate
Ciprofloxacin and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin inhibits CYP1A2, which is the main pathway of rasagiline clearance, so rasagiline concentrations may roughly rise and adverse effects may increase. Reported effects include dyskinesia, orthostatic hypotension, and hallucinations.
What this interaction means in plain words
Ciprofloxacin and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Rasagiline belongs to Central Nervous System.
Why it happens
Inhibition of CYP1A2-mediated rasagiline metabolism by ciprofloxacin.
What to do
Rasagiline labeling advises a lower maximum dose with CYP1A2 inhibitors such as ciprofloxacin, so reduce the dose and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Ciprofloxacin with Rasagiline?
MediHelp rates the interaction as moderate. Ciprofloxacin and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin inhibits CYP1A2, which is the main pathway of rasagiline clearance, so rasagiline concentrations may roughly rise and adverse effects may increase. Reported effects include dyskinesia, orthostatic hypotension, and hallucinations.
How serious is the interaction between Ciprofloxacin and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Rasagiline labeling advises a lower maximum dose with CYP1A2 inhibitors such as ciprofloxacin, so reduce the dose and monitor for adverse effects.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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