Drug interactions
Ciprofloxacin + Repaglinide
Severity: Moderate
Ciprofloxacin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients taking glucose-lowering drugs. Adding ciprofloxacin to repaglinide may cause unpredictable glucose swings.
What this interaction means in plain words
Ciprofloxacin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Repaglinide belongs to Endocrine.
Why it happens
Fluoroquinolone effects on pancreatic insulin release add to the insulin secretagogue action of repaglinide; the mechanism is not fully defined.
What to do
Monitor blood glucose closely when ciprofloxacin is started or stopped. Teach the patient to recognize hypoglycemia symptoms and adjust the antidiabetic dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Ciprofloxacin with Repaglinide?
MediHelp rates the interaction as moderate. Ciprofloxacin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients taking glucose-lowering drugs. Adding ciprofloxacin to repaglinide may cause unpredictable glucose swings.
How serious is the interaction between Ciprofloxacin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when ciprofloxacin is started or stopped. Teach the patient to recognize hypoglycemia symptoms and adjust the antidiabetic dose as needed.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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