Drug interactions
Ciprofloxacin + Ropinirole
Severity: Moderate
Ciprofloxacin and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin inhibits CYP1A2, the main route of ropinirole metabolism, and can substantially raise ropinirole exposure. This may cause greater dopaminergic effects such as nausea, dizziness, somnolence and hypotension.
What this interaction means in plain words
Ciprofloxacin and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Ropinirole belongs to Central Nervous System.
Why it happens
Ciprofloxacin inhibits CYP1A2-mediated clearance of ropinirole.
What to do
Monitor for increased ropinirole effects and reduce the ropinirole dose if they occur. Readjust the dose after ciprofloxacin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Ciprofloxacin with Ropinirole?
MediHelp rates the interaction as moderate. Ciprofloxacin and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin inhibits CYP1A2, the main route of ropinirole metabolism, and can substantially raise ropinirole exposure. This may cause greater dopaminergic effects such as nausea, dizziness, somnolence and hypotension.
How serious is the interaction between Ciprofloxacin and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased ropinirole effects and reduce the ropinirole dose if they occur. Readjust the dose after ciprofloxacin is stopped.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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