Drug interactions
Ciprofloxacin + Sorafenib
Severity: Moderate
Ciprofloxacin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Patients with electrolyte abnormalities or cardiac disease are at greater risk.
What this interaction means in plain words
Ciprofloxacin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Sorafenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain baseline ECG and correct potassium and magnesium. Repeat ECG monitoring during the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ciprofloxacin and Sorafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Ciprofloxacin with Sorafenib?
MediHelp rates the interaction as moderate. Ciprofloxacin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Patients with electrolyte abnormalities or cardiac disease are at greater risk.
How serious is the interaction between Ciprofloxacin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct potassium and magnesium. Repeat ECG monitoring during the combination.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
