Drug interactions
Ciprofloxacin + Sotorasib
Severity: Minor
Ciprofloxacin and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor in vitro and clinically may increase exposure to P-gp substrates. Ciprofloxacin is a weak P-gp substrate, so any change is likely small.
What this interaction means in plain words
Ciprofloxacin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciprofloxacin belongs to Anti Bacterial; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibition of P-gp efflux may slightly increase ciprofloxacin absorption.
What to do
No dose change is usually needed; monitor for ciprofloxacin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Ciprofloxacin with Sotorasib?
MediHelp rates the interaction as minor. Ciprofloxacin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a P-gp inhibitor in vitro and clinically may increase exposure to P-gp substrates. Ciprofloxacin is a weak P-gp substrate, so any change is likely small.
How serious is the interaction between Ciprofloxacin and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for ciprofloxacin adverse effects.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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