Drug interactions
Ciprofloxacin + Tolmetin
Severity: Moderate
Ciprofloxacin and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may raise the risk of CNS stimulation and convulsions. The risk is highest in patients with epilepsy or other seizure predisposition.
What this interaction means in plain words
Ciprofloxacin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Tolmetin belongs to Musculoskeletal.
Why it happens
Fluoroquinolone GABA-A receptor antagonism may be potentiated by NSAIDs, lowering seizure threshold.
What to do
Avoid combining in patients with seizure history or other risks. Otherwise monitor for neurologic symptoms and consider alternative analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Tolmetin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may raise the risk of CNS stimulation and convulsions. The risk is highest in patients with epilepsy or other seizure predisposition.
How serious is the interaction between Ciprofloxacin and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in patients with seizure history or other risks. Otherwise monitor for neurologic symptoms and consider alternative analgesia.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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