Drug interactions
Cisatracurium + Deflazacort
Severity: Moderate
Cisatracurium and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given together with non-depolarizing neuromuscular blockers, particularly during prolonged ICU use, have been linked to acute myopathy with persistent muscle weakness. This may delay recovery of strength and prolong ventilator dependence.
What this interaction means in plain words
Cisatracurium and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Deflazacort belongs to Miscellaneous.
Why it happens
Additive muscle toxicity; corticosteroids and prolonged neuromuscular blockade both contribute to myosin loss and myopathy.
What to do
Limit the dose and duration of the neuromuscular blocker and use neuromuscular monitoring. Assess for weakness and check creatine kinase if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Cisatracurium with Deflazacort?
MediHelp rates the interaction as moderate. Cisatracurium and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given together with non-depolarizing neuromuscular blockers, particularly during prolonged ICU use, have been linked to acute myopathy with persistent muscle weakness. This may delay recovery of strength and prolong ventilator dependence.
How serious is the interaction between Cisatracurium and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the dose and duration of the neuromuscular blocker and use neuromuscular monitoring. Assess for weakness and check creatine kinase if myopathy is suspected.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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