Drug interactions
Cisatracurium + Fludrocortisone
Severity: Minor
Cisatracurium and Fludrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with non-depolarizing neuromuscular blockers have been associated with acute myopathy and prolonged weakness, mainly in critically ill patients. Fludrocortisone is predominantly mineralocorticoid, so the risk is likely lower than with glucocorticoids.
What this interaction means in plain words
Cisatracurium and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cisatracurium belongs to Musculoskeletal; Fludrocortisone belongs to Endocrine.
Why it happens
Possible additive muscle toxicity from corticosteroid exposure and prolonged neuromuscular blockade; this is extrapolated from glucocorticoids.
What to do
Use neuromuscular monitoring and keep cisatracurium exposure as short as possible. Evaluate for persistent weakness after discontinuation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Cisatracurium with Fludrocortisone?
MediHelp rates the interaction as minor. Cisatracurium and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids combined with non-depolarizing neuromuscular blockers have been associated with acute myopathy and prolonged weakness, mainly in critically ill patients. Fludrocortisone is predominantly mineralocorticoid, so the risk is likely lower than with glucocorticoids.
How serious is the interaction between Cisatracurium and Fludrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use neuromuscular monitoring and keep cisatracurium exposure as short as possible. Evaluate for persistent weakness after discontinuation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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