Drug interactions
Cisatracurium + Prednisolone
Severity: Moderate
Cisatracurium and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with nondepolarizing neuromuscular blockers, especially in intensive care, are associated with acute quadriplegic myopathy. Prolonged neuromuscular weakness can delay ventilator weaning and recovery.
What this interaction means in plain words
Cisatracurium and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Prednisolone belongs to Endocrine.
Why it happens
Additive muscle injury and denervation-like effects from corticosteroids and prolonged neuromuscular blockade; the exact mechanism is not fully established.
What to do
Use the shortest effective duration and lowest dose of the blocker, monitor neuromuscular function with train-of-four, and check creatine kinase if weakness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Cisatracurium
Frequently asked questions
Can I take Cisatracurium with Prednisolone?
MediHelp rates the interaction as moderate. Cisatracurium and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with nondepolarizing neuromuscular blockers, especially in intensive care, are associated with acute quadriplegic myopathy. Prolonged neuromuscular weakness can delay ventilator weaning and recovery.
How serious is the interaction between Cisatracurium and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest effective duration and lowest dose of the blocker, monitor neuromuscular function with train-of-four, and check creatine kinase if weakness develops.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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