Drug interactions
Cisatracurium + Tetracycline
Severity: Moderate
Cisatracurium and Tetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline may weakly potentiate non-depolarizing neuromuscular blockers such as cisatracurium. Clinical evidence is sparse, but prolonged blockade is possible.
What this interaction means in plain words
Cisatracurium and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisatracurium belongs to Musculoskeletal; Tetracycline belongs to Anti Bacterial.
Why it happens
Possible additive neuromuscular blockade, potentially through calcium chelation and effects on neuromuscular transmission.
What to do
Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Confirm full recovery before extubation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisatracurium
Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Cisatracurium with Tetracycline?
MediHelp rates the interaction as moderate. Cisatracurium and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracycline may weakly potentiate non-depolarizing neuromuscular blockers such as cisatracurium. Clinical evidence is sparse, but prolonged blockade is possible.
How serious is the interaction between Cisatracurium and Tetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Confirm full recovery before extubation.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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