Drug interactions
Cisplatin + Dacarbazine
Severity: Moderate
Cisplatin and Dacarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can suppress the bone marrow, so together they may cause more pronounced cytopenias. Cisplatin also causes nephrotoxicity, which can complicate supportive care.
What this interaction means in plain words
Cisplatin and Dacarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Dacarbazine belongs to Oncology.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts and renal function before each cycle. Modify doses or delay cycles based on hematologic recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dacarbazine
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Dacarbazine?
MediHelp rates the interaction as moderate. Cisplatin and Dacarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can suppress the bone marrow, so together they may cause more pronounced cytopenias. Cisplatin also causes nephrotoxicity, which can complicate supportive care.
How serious is the interaction between Cisplatin and Dacarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function before each cycle. Modify doses or delay cycles based on hematologic recovery.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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