Drug interactions
Cisplatin + Dichlorphenamide
Severity: Moderate
Cisplatin and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that causes bicarbonate and potassium loss, and cisplatin can cause renal tubular damage with potassium and magnesium wasting and metabolic acidosis. Together they may produce significant hypokalemia and acidosis.
What this interaction means in plain words
Cisplatin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive renal potassium and bicarbonate loss from carbonic anhydrase inhibition and cisplatin tubular toxicity.
What to do
Monitor serum bicarbonate, potassium and magnesium regularly and correct abnormalities. Reduce the dichlorphenamide dose or stop it if acidosis persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Cisplatin with Dichlorphenamide?
MediHelp rates the interaction as moderate. Cisplatin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that causes bicarbonate and potassium loss, and cisplatin can cause renal tubular damage with potassium and magnesium wasting and metabolic acidosis. Together they may produce significant hypokalemia and acidosis.
How serious is the interaction between Cisplatin and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate, potassium and magnesium regularly and correct abnormalities. Reduce the dichlorphenamide dose or stop it if acidosis persists.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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