Drug interactions
Cisplatin + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Cisplatin and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin is nephrotoxic and ototoxic, and tenofovir disoproxil fumarate and cobicistat can also impair renal function. Together they raise the risk of acute kidney injury and tubular damage.
What this interaction means in plain words
Cisplatin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from platinum tubular injury, tenofovir proximal tubular toxicity and cobicistat inhibition of creatinine secretion.
What to do
Avoid the combination where possible by using a non-tenofovir regimen during cisplatin. If unavoidable, monitor serum creatinine, electrolytes and urinary protein closely and ensure hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Cisplatin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin is nephrotoxic and ototoxic, and tenofovir disoproxil fumarate and cobicistat can also impair renal function. Together they raise the risk of acute kidney injury and tubular damage.
How serious is the interaction between Cisplatin and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible by using a non-tenofovir regimen during cisplatin. If unavoidable, monitor serum creatinine, electrolytes and urinary protein closely and ensure hydration.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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