Drug interactions
Cisplatin + Influenza a vaccine
Severity: Moderate
Cisplatin and Influenza a vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy can reduce antibody responses to influenza vaccines, including H5N1 vaccines. Patients may be inadequately protected despite vaccination.
What this interaction means in plain words
Cisplatin and Influenza a vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression impairs vaccine immunogenicity.
What to do
Where possible vaccinate before chemotherapy or at the least myelosuppressed point in the cycle, and do not rely on a single dose for protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Influenza a vaccine?
MediHelp rates the interaction as moderate. Cisplatin and Influenza a vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic chemotherapy can reduce antibody responses to influenza vaccines, including H5N1 vaccines. Patients may be inadequately protected despite vaccination.
How serious is the interaction between Cisplatin and Influenza a vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible vaccinate before chemotherapy or at the least myelosuppressed point in the cycle, and do not rely on a single dose for protection.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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