Drug interactions
Cisplatin + Ioversol
Severity: Moderate
Cisplatin and Ioversol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast media can cause contrast-associated kidney injury, and cisplatin is itself nephrotoxic. Combined exposure increases the risk of acute kidney injury.
What this interaction means in plain words
Cisplatin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal tubular toxicity and hemodynamic effects.
What to do
Ensure adequate hydration and check serum creatinine before and after contrast. Where feasible, separate contrast studies from cisplatin dosing and consider avoiding other nephrotoxins.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Ioversol?
MediHelp rates the interaction as moderate. Cisplatin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast media can cause contrast-associated kidney injury, and cisplatin is itself nephrotoxic. Combined exposure increases the risk of acute kidney injury.
How serious is the interaction between Cisplatin and Ioversol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check serum creatinine before and after contrast. Where feasible, separate contrast studies from cisplatin dosing and consider avoiding other nephrotoxins.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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