Drug interactions
Cisplatin + Meningococcal group b vaccine
Severity: Moderate
Cisplatin and Meningococcal group b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patients receiving cytotoxic chemotherapy may mount a weaker antibody response to meningococcal B vaccine. The vaccine is non-live, so the main concern is reduced effectiveness rather than safety.
What this interaction means in plain words
Cisplatin and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate before starting chemotherapy when possible or after immune recovery, and consider revaccination or serologic assessment if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Meningococcal group b vaccine?
MediHelp rates the interaction as moderate. Cisplatin and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients receiving cytotoxic chemotherapy may mount a weaker antibody response to meningococcal B vaccine. The vaccine is non-live, so the main concern is reduced effectiveness rather than safety.
How serious is the interaction between Cisplatin and Meningococcal group b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting chemotherapy when possible or after immune recovery, and consider revaccination or serologic assessment if given during treatment.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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