Drug interactions
Cisplatin + Neomycin po
Severity: Moderate
Cisplatin and Neomycin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed in normal conditions, but systemic uptake can occur with damaged mucosa or renal impairment. Because cisplatin is nephrotoxic and ototoxic, any absorbed neomycin could add to kidney and hearing injury.
What this interaction means in plain words
Cisplatin and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity and ototoxicity if systemic neomycin exposure occurs.
What to do
Monitor renal function and hearing, especially with prolonged neomycin use, bowel disease or reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Neomycin po?
MediHelp rates the interaction as moderate. Cisplatin and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin is poorly absorbed in normal conditions, but systemic uptake can occur with damaged mucosa or renal impairment. Because cisplatin is nephrotoxic and ototoxic, any absorbed neomycin could add to kidney and hearing injury.
How serious is the interaction between Cisplatin and Neomycin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hearing, especially with prolonged neomycin use, bowel disease or reduced renal function.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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