Drug interactions
Cisplatin + Paclitaxel protein bound
Severity: Minor
Cisplatin and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin can cause renal impairment and reduce the clearance of co-administered drugs, which might raise nab-paclitaxel exposure. In practice the combination is used routinely in regimens, and the contribution of this effect to toxicity is small and poorly defined. Overlapping neuropathy and myelosuppression are the more relevant concerns.
What this interaction means in plain words
Cisplatin and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduction in renal elimination of paclitaxel from cisplatin nephrotoxicity; the effect is not well established, and paclitaxel is mainly cleared by hepatic metabolism.
What to do
Monitor renal function, blood counts and peripheral neuropathy during treatment. Adjust nab-paclitaxel dose according to its labeled toxicity-based criteria.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Cisplatin and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cisplatin can cause renal impairment and reduce the clearance of co-administered drugs, which might raise nab-paclitaxel exposure. In practice the combination is used routinely in regimens, and the contribution of this effect to toxicity is small and poorly defined. Overlapping neuropathy and myelosuppression are the more relevant concerns.
How serious is the interaction between Cisplatin and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood counts and peripheral neuropathy during treatment. Adjust nab-paclitaxel dose according to its labeled toxicity-based criteria.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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