Drug interactions
Cisplatin + Peramivir
Severity: Moderate
Cisplatin and Peramivir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is cleared by the kidney, and cisplatin can reduce renal function, leading to higher peramivir exposure. This may increase peramivir adverse effects if kidney function declines.
What this interaction means in plain words
Cisplatin and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cisplatin-induced renal impairment reduces renal elimination of peramivir.
What to do
Check renal function and adjust the peramivir dose to creatinine clearance per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Peramivir?
MediHelp rates the interaction as moderate. Cisplatin and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peramivir is cleared by the kidney, and cisplatin can reduce renal function, leading to higher peramivir exposure. This may increase peramivir adverse effects if kidney function declines.
How serious is the interaction between Cisplatin and Peramivir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function and adjust the peramivir dose to creatinine clearance per labeling.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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