Drug interactions
Cisplatin + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Cisplatin and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations containing these salts can cause fluid loss and electrolyte shifts. Cisplatin also causes vomiting, dehydration, renal magnesium and potassium wasting, so combined use may worsen dehydration, renal impairment and arrhythmia risk.
What this interaction means in plain words
Cisplatin and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte disturbances leading to volume depletion and potential kidney injury.
What to do
Avoid bowel preparation around cisplatin dosing when possible, and ensure hydration with monitoring of creatinine, magnesium and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Cisplatin and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations containing these salts can cause fluid loss and electrolyte shifts. Cisplatin also causes vomiting, dehydration, renal magnesium and potassium wasting, so combined use may worsen dehydration, renal impairment and arrhythmia risk.
How serious is the interaction between Cisplatin and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid bowel preparation around cisplatin dosing when possible, and ensure hydration with monitoring of creatinine, magnesium and potassium.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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