Drug interactions
Cisplatin + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Cisplatin and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin commonly causes renal loss of potassium and magnesium, and bowel preparations can cause fluid and electrolyte shifts and diarrhea. Together they may worsen electrolyte disturbance and dehydration, increasing the risk of arrhythmia and renal injury.
What this interaction means in plain words
Cisplatin and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive electrolyte disturbance and volume depletion from cisplatin tubulopathy and osmotic bowel cleansing.
What to do
Ensure adequate hydration and check serum potassium, magnesium and creatinine before and after bowel preparation. Replace electrolytes as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Cisplatin and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cisplatin commonly causes renal loss of potassium and magnesium, and bowel preparations can cause fluid and electrolyte shifts and diarrhea. Together they may worsen electrolyte disturbance and dehydration, increasing the risk of arrhythmia and renal injury.
How serious is the interaction between Cisplatin and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check serum potassium, magnesium and creatinine before and after bowel preparation. Replace electrolytes as needed.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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