Drug interactions
Cisplatin + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Cisplatin and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations can cause fluid loss and electrolyte disturbances. Cisplatin already causes vomiting, renal magnesium and potassium wasting and nephrotoxicity, so dehydration and electrolyte shifts can worsen kidney injury and raise the risk of arrhythmias or seizures.
What this interaction means in plain words
Cisplatin and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on fluid and electrolyte balance, with volume depletion increasing cisplatin renal toxicity.
What to do
Avoid giving the bowel preparation around cisplatin infusions unless essential, and ensure adequate hydration. Check serum creatinine, potassium, magnesium and calcium before and after use and replace deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Cisplatin and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations can cause fluid loss and electrolyte disturbances. Cisplatin already causes vomiting, renal magnesium and potassium wasting and nephrotoxicity, so dehydration and electrolyte shifts can worsen kidney injury and raise the risk of arrhythmias or seizures.
How serious is the interaction between Cisplatin and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the bowel preparation around cisplatin infusions unless essential, and ensure adequate hydration. Check serum creatinine, potassium, magnesium and calcium before and after use and replace deficits.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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