Drug interactions
Cisplatin + Sodium thiosulfate
Severity: Moderate
Cisplatin and Sodium thiosulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium thiosulfate inactivates cisplatin and can reduce its antitumor activity if given too close in time. It is used to reduce cisplatin ototoxicity, so timing is critical.
What this interaction means in plain words
Cisplatin and Sodium thiosulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Sodium thiosulfate belongs to Miscellaneous.
Why it happens
Thiosulfate binds platinum, neutralizing cisplatin cytotoxicity.
What to do
Give sodium thiosulfate at least 6 hours after the end of the cisplatin infusion. Do not give it with or before cisplatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Sodium thiosulfate?
MediHelp rates the interaction as moderate. Cisplatin and Sodium thiosulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium thiosulfate inactivates cisplatin and can reduce its antitumor activity if given too close in time. It is used to reduce cisplatin ototoxicity, so timing is critical.
How serious is the interaction between Cisplatin and Sodium thiosulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give sodium thiosulfate at least 6 hours after the end of the cisplatin infusion. Do not give it with or before cisplatin.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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