Drug interactions
Cisplatin + Streptozocin
Severity: Major
Cisplatin and Streptozocin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and streptozocin causes dose-related renal tubular toxicity. Given together, the risk and severity of renal impairment increase, and additive myelosuppression and ototoxicity concerns also apply.
What this interaction means in plain words
Cisplatin and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity through proximal tubular injury from both agents, plus overlapping bone marrow suppression.
What to do
Avoid the combination where possible or use with aggressive hydration. Monitor serum creatinine, electrolytes and blood counts before each cycle and reduce doses if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Streptozocin?
MediHelp rates the interaction as major. Cisplatin and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidney, and streptozocin causes dose-related renal tubular toxicity. Given together, the risk and severity of renal impairment increase, and additive myelosuppression and ototoxicity concerns also apply.
How serious is the interaction between Cisplatin and Streptozocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible or use with aggressive hydration. Monitor serum creatinine, electrolytes and blood counts before each cycle and reduce doses if renal function declines.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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