Drug interactions
Cisplatin + Tenofovir df
Severity: Major
Cisplatin and Tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin damages the renal tubules, and tenofovir disoproxil is also associated with proximal tubular toxicity and is eliminated by the kidney. Combined use can worsen renal function and raise tenofovir exposure, increasing the risk of kidney injury and Fanconi-type syndrome.
What this interaction means in plain words
Cisplatin and Tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive proximal tubular nephrotoxicity, with reduced renal clearance of tenofovir when kidney function falls.
What to do
Consider an alternative antiretroviral such as tenofovir alafenamide or a non-nephrotoxic regimen during cisplatin therapy. If continued, monitor creatinine, phosphate and electrolytes closely and adjust the tenofovir dose to renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Tenofovir df?
MediHelp rates the interaction as major. Cisplatin and Tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin damages the renal tubules, and tenofovir disoproxil is also associated with proximal tubular toxicity and is eliminated by the kidney. Combined use can worsen renal function and raise tenofovir exposure, increasing the risk of kidney injury and Fanconi-type syndrome.
How serious is the interaction between Cisplatin and Tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiretroviral such as tenofovir alafenamide or a non-nephrotoxic regimen during cisplatin therapy. If continued, monitor creatinine, phosphate and electrolytes closely and adjust the tenofovir dose to renal function.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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