Drug interactions
Cisplatin + Thalidomide
Severity: Moderate
Cisplatin and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cisplatin causes dose-related sensory neuropathy, and thalidomide is also neurotoxic. Using them together increases the likelihood of earlier or more severe neuropathy, which may be irreversible.
What this interaction means in plain words
Cisplatin and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Thalidomide belongs to Miscellaneous.
Why it happens
Additive peripheral neurotoxicity.
What to do
Examine neurological function at baseline and before each cycle. Reduce the dose or discontinue the responsible agent when neuropathy progresses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thalidomide
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Thalidomide?
MediHelp rates the interaction as moderate. Cisplatin and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cisplatin causes dose-related sensory neuropathy, and thalidomide is also neurotoxic. Using them together increases the likelihood of earlier or more severe neuropathy, which may be irreversible.
How serious is the interaction between Cisplatin and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Examine neurological function at baseline and before each cycle. Reduce the dose or discontinue the responsible agent when neuropathy progresses.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
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