Drug interactions
Cisplatin + Thiotepa
Severity: Moderate
Cisplatin and Thiotepa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress the bone marrow, so combining them increases the depth and duration of neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding.
What this interaction means in plain words
Cisplatin and Thiotepa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cisplatin belongs to Oncology; Thiotepa belongs to Oncology.
Why it happens
Additive myelosuppression from two cytotoxic DNA-damaging agents.
What to do
Monitor complete blood counts frequently and adjust doses or delay cycles according to nadir counts. Provide supportive care such as growth factors or transfusions when indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Thiotepa
- Bendamustine + Thiotepa Major
- Chlorambucil + Thiotepa Major
- Clarithromycin + Thiotepa Major
- Cyclophosphamide + Thiotepa Major
- Dacarbazine + Thiotepa Major
- Deferiprone + Thiotepa Major
Frequently asked questions
Can I take Cisplatin with Thiotepa?
MediHelp rates the interaction as moderate. Cisplatin and Thiotepa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress the bone marrow, so combining them increases the depth and duration of neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding.
How serious is the interaction between Cisplatin and Thiotepa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and adjust doses or delay cycles according to nadir counts. Provide supportive care such as growth factors or transfusions when indicated.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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