Drug interactions
Cisplatin + Tobramycin inhaled
Severity: Moderate
Cisplatin and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic aminoglycosides and cisplatin have additive nephrotoxicity and ototoxicity. Inhaled tobramycin has low systemic absorption, but accumulation is possible, especially in renal impairment.
What this interaction means in plain words
Cisplatin and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal tubular and cochlear toxicity from platinum and aminoglycoside exposure.
What to do
Monitor renal function, serum tobramycin levels if indicated, and hearing. Consider an alternative inhaled antibiotic when cisplatin is being given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisplatin and Tobramycin inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Cisplatin and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic aminoglycosides and cisplatin have additive nephrotoxicity and ototoxicity. Inhaled tobramycin has low systemic absorption, but accumulation is possible, especially in renal impairment.
How serious is the interaction between Cisplatin and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, serum tobramycin levels if indicated, and hearing. Consider an alternative inhaled antibiotic when cisplatin is being given.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
