Drug interactions
Citalopram + Clofazimine
Severity: Major
Citalopram and Clofazimine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and citalopram's effect is dose dependent. Together they raise the risk of torsades de pointes, especially with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Citalopram and Clofazimine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Clofazimine belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation.
What to do
Check baseline and follow-up ECG, correct potassium and magnesium, keep citalopram at or below the maximum recommended dose, or choose a non-QT-prolonging antidepressant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clofazimine
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Clofazimine?
MediHelp rates the interaction as major. Citalopram and Clofazimine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and citalopram's effect is dose dependent. Together they raise the risk of torsades de pointes, especially with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Citalopram and Clofazimine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and follow-up ECG, correct potassium and magnesium, keep citalopram at or below the maximum recommended dose, or choose a non-QT-prolonging antidepressant.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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