Drug interactions
Bedaquiline + Clofazimine
Severity: Major
Bedaquiline and Clofazimine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and combined use can produce additive QTc prolongation. This raises the risk of torsades de pointes and other serious ventricular arrhythmias, especially with other risk factors.
What this interaction means in plain words
Bedaquiline and Clofazimine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Clofazimine belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization (QT) by both agents.
What to do
Obtain baseline and periodic ECGs and correct potassium, magnesium and calcium abnormalities. Stop the drugs if serious ventricular arrhythmia occurs or QTc exceeds 500 ms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Other interactions of Clofazimine
Frequently asked questions
Can I take Bedaquiline with Clofazimine?
MediHelp rates the interaction as major. Bedaquiline and Clofazimine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and combined use can produce additive QTc prolongation. This raises the risk of torsades de pointes and other serious ventricular arrhythmias, especially with other risk factors.
How serious is the interaction between Bedaquiline and Clofazimine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct potassium, magnesium and calcium abnormalities. Stop the drugs if serious ventricular arrhythmia occurs or QTc exceeds 500 ms.
What other medicines interact with Bedaquiline?
MediHelp also lists interactions of Bedaquiline with, for example, Ziprasidone, Alfuzosin, Amiodarone. The full list is on the Bedaquiline page.
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