Drug interactions
Amisulpride + Clofazimine
Severity: Major
Amisulpride and Clofazimine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so combined use increases the risk of torsades de pointes. Risk is higher with electrolyte disturbance, bradycardia or underlying cardiac disease.
What this interaction means in plain words
Amisulpride and Clofazimine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Clofazimine belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation through cardiac potassium channel blockade.
What to do
Avoid combination where possible; if needed, obtain baseline and follow-up ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clofazimine
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Clofazimine?
MediHelp rates the interaction as major. Amisulpride and Clofazimine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so combined use increases the risk of torsades de pointes. Risk is higher with electrolyte disturbance, bradycardia or underlying cardiac disease.
How serious is the interaction between Amisulpride and Clofazimine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible; if needed, obtain baseline and follow-up ECGs and correct potassium and magnesium.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Azithromycin, Bedaquiline. The full list is on the Clofazimine page.
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