Drug interactions
Citalopram + Dacomitinib
Severity: Moderate
Citalopram and Dacomitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which contributes partly to citalopram metabolism. The expected increase in citalopram exposure is limited since CYP2C19 and CYP3A4 also metabolize it, but it could add to QT-related risk.
What this interaction means in plain words
Citalopram and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Dacomitinib belongs to Oncology.
Why it happens
Dacomitinib inhibition of CYP2D6 reduces one pathway of citalopram clearance.
What to do
Monitor for citalopram adverse effects and consider an ECG, especially at higher doses. Reduce the citalopram dose if tolerability or QTc is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Citalopram with Dacomitinib?
MediHelp rates the interaction as moderate. Citalopram and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6, which contributes partly to citalopram metabolism. The expected increase in citalopram exposure is limited since CYP2C19 and CYP3A4 also metabolize it, but it could add to QT-related risk.
How serious is the interaction between Citalopram and Dacomitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for citalopram adverse effects and consider an ECG, especially at higher doses. Reduce the citalopram dose if tolerability or QTc is a concern.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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