Drug interactions
Citalopram + Dalteparin
Severity: Moderate
Citalopram and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram impairs platelet function and may increase bleeding, particularly gastrointestinal bleeding, when used with anticoagulants. The risk is added to the anticoagulant effect of dalteparin.
What this interaction means in plain words
Citalopram and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Dalteparin belongs to Cardiovascular.
Why it happens
SSRI-mediated depletion of platelet serotonin reduces platelet aggregation, adding to dalteparin anticoagulation.
What to do
Monitor for bleeding signs and haemoglobin, especially in older patients or those with prior GI bleeding. Consider a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Dalteparin?
MediHelp rates the interaction as moderate. Citalopram and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram impairs platelet function and may increase bleeding, particularly gastrointestinal bleeding, when used with anticoagulants. The risk is added to the anticoagulant effect of dalteparin.
How serious is the interaction between Citalopram and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and haemoglobin, especially in older patients or those with prior GI bleeding. Consider a proton pump inhibitor in high-risk patients.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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