Drug interactions
Citalopram + Difelikefalin
Severity: Minor
Citalopram and Difelikefalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and citalopram may add to CNS effects. The combination can impair alertness and increase fall risk in dialysis patients.
What this interaction means in plain words
Citalopram and Difelikefalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS effects, as difelikefalin is a peripherally restricted kappa-opioid agonist with some sedative effect.
What to do
Watch for excess drowsiness or dizziness, and advise caution with driving and fall precautions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Citalopram with Difelikefalin?
MediHelp rates the interaction as minor. Citalopram and Difelikefalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin can cause somnolence and dizziness, and citalopram may add to CNS effects. The combination can impair alertness and increase fall risk in dialysis patients.
How serious is the interaction between Citalopram and Difelikefalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for excess drowsiness or dizziness, and advise caution with driving and fall precautions.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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