Drug interactions
Amobarbital + Difelikefalin
Severity: Moderate
Amobarbital and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and adding a barbiturate may intensify CNS depression. This raises the risk of oversedation and falls in dialysis patients.
What this interaction means in plain words
Amobarbital and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depressant effects; difelikefalin is a peripherally restricted kappa-opioid agonist with some CNS effects.
What to do
Monitor for excessive sedation, dizziness and falls, and reduce the dose of the sedative if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
- Baclofen + Difelikefalin Moderate
Frequently asked questions
Can I take Amobarbital with Difelikefalin?
MediHelp rates the interaction as moderate. Amobarbital and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and adding a barbiturate may intensify CNS depression. This raises the risk of oversedation and falls in dialysis patients.
How serious is the interaction between Amobarbital and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and falls, and reduce the dose of the sedative if these occur.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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