Drug interactions
Amitriptyline + Difelikefalin
Severity: Moderate
Amitriptyline and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa-opioid agonist, can cause somnolence and dizziness, and amitriptyline adds to these sedative effects. The combination may increase the risk of drowsiness and falls, particularly in dialysis patients.
What this interaction means in plain words
Amitriptyline and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depressant effects from kappa-opioid receptor agonism and the sedative properties of amitriptyline.
What to do
Monitor for excessive sedation, dizziness and falls after starting or changing either drug. Reduce doses if sedation becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
- Baclofen + Difelikefalin Moderate
Frequently asked questions
Can I take Amitriptyline with Difelikefalin?
MediHelp rates the interaction as moderate. Amitriptyline and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a kappa-opioid agonist, can cause somnolence and dizziness, and amitriptyline adds to these sedative effects. The combination may increase the risk of drowsiness and falls, particularly in dialysis patients.
How serious is the interaction between Amitriptyline and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and falls after starting or changing either drug. Reduce doses if sedation becomes troublesome.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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